End-stage kidney - Libre Pathology


pathology outlines kidney

Acute interstitial nephritis (AIN) describes a lesion with interstitial edema with a mononuclear cell infiltrate invading the interstitium and tubules, composed mostly of T lymphocytes. There are scattered plasma cells and macrophages, occasionally with non-necrotizing granulomas, and variable presence of eosinophils. When inflammation is due to infection, the lesion is diagnosed according to. Pathology Outlines Kidney non-tumor Pathology Outlines is a Web-site with a number of links with pathology images. There are short resumes of renal diseases. It is a great place. ovwerijssels.gq (kidney) A visual survey of urological pathology. This is the microscopic appearance of an acute renal infarct. Compare the intact architecure of the normal kidney cortex with the hyperemic kidney that is dying, then the pale pink infarcted kidney in which both tubules and glomeruli are dead. This is acute coagulative necrosis, which initially leaves the pale outlines of the infarcted cells.

Lupus nephritis

Review Items for Week Renal Pathology. Some therapeutic response was obtained with chemical agents and X-radiation. Death followed pneumonia and sepsis. The spaces between bony spicules are filled with hematopoietic cells.

Not the large numbers of round, empty fat cells present within the marrow space, pathology outlines kidney. The fat is lost during processing into paraffin sections. Megakaryocytes can be readily identified, since they are approximately 5-fold larger than most bone marrow cells and contain strongly eosinophilic cytoplasm and multiple pathology outlines kidney. Which of the following cytogenetic alterations is associated with multiple myeloma?

Clinical History : A year-old boy presented with cervical lymphadenopathy and was found to have a mediastinal mass. The neck node was biopsied. The lymph node contains a cortex which includes the lymphoid follicles and a medulla which is looser tissue containing the lymphatic channels and blood vessels. Clinical History: A year-old male had a "neurogenic bladder", caused by a spinal cord tumor.

He had multiple bladder infections which were treated with antibiotics. He had surgery to remove the tumor. Postoperatively, he developed fever and costovertebral angle tenderness which did not respond to antibiotics.

He expired and an autopsy was performed. The kidney excretes soluble waste from the body and controls electrolyte balance. It consists of the cortex and the medulla. Within the outer cortex, glomeruli with delicate capillary loops are seen. The basement membrane is thin and without inflammation or thickening. The interstitium demonstrates no evidence of inflammation pathology outlines kidney fibrosis.

In the areas between the glomeruli, tubules and arterioles are seen. The tubules are intact. The vessels exhibit no narrowing or wall thickening. The inner medulla of the kidney contains only tubules and blood vessels. Larger arteries and veins are located at the interface between cortex and medulla. Clinical History: A year-old woman had experienced increasing malaise with nocturia and polyuria for the past year.

Serum BUN and creatinine were elevated. She developed worsening renal failure and died of pneumonia. Clinical History: This 55 year pathology outlines kidney female first came to medical attention when she complained of frequent urination, increased thirst and weight loss at age Insulin dependent diabetes was diagnosed. She developed proteinuria at age Her disease progressed until she became dialysis dependent at age She expired due to pneumonia after a below knee amputation. Non-enzymatic glycosylation is fundamental to basement membrane thickening in the eye and kidney through:.

What type of glomerular lesion is seen characteristically in diabetic nephropathy? Absolutely critical information you must know to practice medicine is in bold font. Important information that will be needed for routine patient care is in regular font. Information about less common diseases that you may encounter in clinical practice and that will probably appear on examinations is in italics. Course Information, pathology outlines kidney.

Contact Faculty. Duke Anatomy. Duke Embryology, pathology outlines kidney. Duke Histology. Duke Neuro. Autopsy Information. UMich Basic Path. UMich Pathology. Summary of Gross Findings - click here Many of the bones contained poorly delineated, soft gelatinous red tumor masses of various dimensions.

Plain film of the skull shows sharply punched out bone lesions. Summary of Microscopic Findings - click here The marrow is heavily infiltrated with plasma cells which vary in degree of maturation. Islets of normoblasts are present, but granulocytes and megakaryocytes are markedly decreased.

There is considerable loss of pathology outlines kidney and cortical bone. Review Normal Histology - click here Specimen No. Summary of Gross Findings - click here The lymph node was enlarged, and remarkable for fibrous bands separating areas of firm, fleshy material.

Summary of Microscopic Findings - click here The normal lymph node architecture is completely destroyed. In its place are thick bands of collagen, separating islands of lymphoid tissue. In some of these nodules, there is a mixed infiltrate consisting of lymphocytes, eosinophils, pathology outlines kidney, some neutrophils and plasma cells, and numerous large cells with highly pleomorphic nuclei.

Nuclei are frequently multi lobulated but classic binucleate Reed-Stemberg cells are uncommon. Many cells are so-called "lacunar variants", with nuclei which have artefactually shrunken away from their cytoplasmic borders, leaving a clear space than can often easily be appreciated at low power. Review Normal Histology - click here Norm No. Gram stain of a blood culture showed gram negative rods.

A catheterized urine specimen was obtained before death. Greater thancolonies of E. Coli were cultured. The pathology outlines kidney was distended, with a thickened, trabeculated wall, pathology outlines kidney.

There was a bilateral hydroureter and hydronephrosis. The left kidney was swollen, and the cut surface showed soft foci of yellow streaks extending toward the pelvis. Summary of Microscopic Findings - click here Naked eye examination of the slide reveals dark streaks extending from the outer cortex to the inner medulla, pathology outlines kidney. Microscopically these are foci of acute inflammation, including necrosis and hemorrhage, with masses of polymorphonuclear leukocytes that are also found in many tubules.

Summary of Gross Findings - click here The kidneys are small with irregular and coarse U-shaped corticomedullary scars overlying dilated, blunt, deformed calyces.

Extensive scarring is noted at the hilum of each kidney. Evidence of hydronephrosis and cortical thinning is also observed. Summary of Microscopic Findings - click here Interstitial tissue shows prominent infiltration by pathology outlines kidney and plasma cells, and occasional polymorphonuclear neutrophils; irregular fibrous scars and peri-glomerular fibrosis.

Tubules are dilated, many filled with eosinophilic casts giving the region a "thyroid-like" appearance. A few tubules contain polymorphonuclear neutrophils, pathology outlines kidney, indicating that this is an active exacerbation of a chronic pyelonephritis.

Arteries are markedly thickened, with intimal proliferation resulting in narrowing of the lumen. Many arterioles show hyaline changes in their walls.

Most glomeruli are replaced by fibrous tissue. A few are surprisingly normal in appearance with intact capillaries. There is a prominent peri-glomerular fibrosis in many regions with a thick rim of fibrous tissue circling the outside of Bowman's capsule.

Summary of Gross Findings - click here The kidneys were small and each pathology outlines kidney grams. The surface was irregular with pits and small cysts.

Summary of Microscopic Findings - click here There are glomerular lesions consisting of diffuse and nodular glomeroslerosis. Nodular glomerulosclerosis or Kimmelstiel-Wilson lesions are ball-like deposits of PAS positive material which contain trapped mesangial cells. Diffuse glomeruloslerosis usually appears as global sclerosis of the glomerular tuft, pathology outlines kidney. Chronic pyelonephritis, arterio and arteriolo nephrosclerosis as seen here are also typical findings in diabetic kidneys.

Normal Lab Values. Suggested readings from Robbins 8th ed. Anemias: pp. Image Gallery: Summary of Gross Findings - click here Many of the bones contained poorly delineated, soft gelatinous red tumor masses of various dimensions. Bence Jones protein.

Kimmelstiel-Wilson disease. Birbeck granule HX body. Philadelphia chromosome. Plummer-Vinson syndrome. G6PD screen. Schilling test, pathology outlines kidney. Cabot ring.


Kidney - Libre Pathology


pathology outlines kidney


hypertensive nephropathy pathology outlines Kidney non-tumor - Hemolytic uremia syndrome / thrombotic. TTP/HUS = fibrin thrombi also think of cyclosporine and tacrolimus toxicity (see foamy tubular cells too), HELLP, malignant HTN, scleroderma also see MUCOID INTIMAL EDEMA See more. Return to the organ system pathology menu. Tutorials. Go to the tutorial on urinalysis. Go to the tutorial on renal cystic diseases. Normal and Incidental Findings. Kidney failure due to acute tubular necrosis (nowadays, "acute renal injury", but the pathology is the same) is a common, potentially lethal complication in the intensive-care unit. Renal insufficiency due to underperfusion (dehydration, shock or a failing heart) or due to obstruction are extremely common.